Johns Hopkins Clinical Research Study

Functional Neuroimaging of Nimodipine in Healthy Adults

IRB Number: NA_00070426
Principal Investigator: Bigos, Kristin

Study Description:

This study will investigate the neural effects of nimodipine, a safe FDA-approved calcium channel blocker, has on brain function.  Healthy subjects will perform several simple cognitive and emotional tasks while having their brain activity measured using functional magnetic resonance imaging (fMRI).  Subjects will have blood drawn to determine their genotype corresponding to a specific calcium channel gene, and subjects with different genetic variants will be grouped together for comparison of fMRI activity.  This study will have 30 subjects.

Eligibility Criteria:

Inclusion Criteria:

  • Male
  • Age 18-35
  • Caucasian
  • Healthy
  • Right Handed

Exclusion Criteria:

  • Metal medical devices, pacemakers, defibrillator, metallic fragments, or other metal in the body
  • Smoking
  • Psychotropic substance or other drug use
  • Past or current low blood pressure
  • Past or current psychiatric disorder (including stroke, brain tumor, epilepsy, Alzheimer’s, Parkinson’s, or Huntington’s disease)
  • History of loss of consciousness, concussion, or other significant head trauma

Recruitment Contact Name:Molly O'Rourke
Contact Phone:410-955-1217
Contact E-Mail: PharmTeam@libd.org

Location of Study Visits:

  • Johns Hopkins Hospital East Baltimore Campus

Study will provide compensation: Yes


  • Functional Neuroimaging
  • Brain
  • Calcium Channels, L-Type