Johns Hopkins Clinical Research Study

A Study of Muscle Strength Maintenance in Older Adults

IRB Number: NA_00078435
Principal Investigator: Walston, Jeremy

Study Description:

This research study is being done to see whether losartan can prevent the decrease in strength associated with aging.

Muscle loss is associated with aging and has multiple symptoms such as weakness, slowness, and fatigue (tiredness). Older adults with muscle weakness have a higher risk of falls and disability. In addition, the loss of independence for older adults can lead to a poorer quality of life.

Recently, it was discovered that losartan, a medication commonly used to treat high blood pressure, had slowed the strength decline seen in older mice. In addition, it allowed injured mice skeletal muscle to heal faster. Therefore, we would like to see if losartan can do the same for older adults.

Eligibility Criteria:

  • Adults age 70 and over
  • Are not using an angiotensin-receptor blocker (i.e. losartan, valsartan) or angiotensin-converting enzyme inhibitors (i.e. lisinopril, enalapril)
  • Are not regularly using non-steroidal anti-inflammatory agents (i.e. ibuprofen or naproxen) or steroids
  • Do not have a history of chronic kidney disease or congestive heart failure
  • Do not have cognitive impairment

Recruitment Contact Name:Ora White
Contact Phone:410-550-2113
Contact E-Mail: jlee447@jhmi.edu

Location of Study Visits:

  • Johns Hopkins Bayview Medical Center

Study will provide compensation: Yes


  • Exercise Test
  • Losartan